SBI's ProMax™ drug target database is composed of thousands of high-quality, 3-D protein structures generated from primary sequence data employing SBI's advanced computational technologies in concert with the empirical results of wet chemistry. There are hundreds of protein families in ProMax™ which include growth factors, proteases, kinases, hormonal proteins, signal transduction proteins, cytokines, and much more. Emphasis is placed on proteins that can be used as drug targets.

Each ProMax™ 3-D protein structure is generated using SBI's proprietary Augmented Homology Modeling™ process. SBI's technology effectively addresses the major limitations of conventional modeling to produce protein structures of X-ray crystallographic quality, with a tremendous cost-benefit. Hundreds of new structures and families are being added on a regular basis.

The ProMax™ database is used in multiple aspects of the pharmaceutical development process to enhance efficiency, reduce cost, and increase the probability of success. ProMax™ also provides chemical and biological scientists, as well as molecular modelers, with an immediate encyclopedia of proprietary structures.

 

Features:

• 3-D protein structures of X-ray crystallographic quality

• Comprehensive quality control and quality assurance

• Hundreds of searchable protein families

• Thousands of protein structures available

• Regularly updated with new structures and protein data

• Contained within a relational database format

• Browser-based viewer

• Keyword, Swiss-Prot, and GenBank accession number searching

• Structure motif search tool

• Structure homology searching

• Custom indexing and categorization of structures

• Customized toolbox for specific needs